目的分析无创机械通气在重症呼吸衰竭伴意识障碍患者治疗中的应用效果。方法选取2010年1月—2014年1月安福县人民医院收治的慢性阻塞性肺疾病(COPD)合并重症呼吸衰竭患者50例,根据患者是否伴意识障碍分为观察组〔格拉斯哥昏迷评分(GCS)<10分〕24例和对照组(GCS≥10分)26例。两组患者均行无创机械通气治疗,比较两组患者治疗情况和治疗前后动脉血气分析指标变化,包括PaO2、PaCO2和pH值。结果两组患者无创机械通气救治成功率比较,差异无统计学意义(79.1%比80.7%,P>0.05)。两组患者治疗前后PaO2、PaCO2及pH值比较,差异无统计学意义(P>0.05)。两组患者治疗后PaO2和pH值高于治疗前,PaCO2低于治疗前(P<0.05)。结论无创机械通气对重症呼吸衰竭伴或不伴意识障碍患者的治疗效果类似,可以改善患者血气分析指标。 Objective To analyze the effect of non-invasive mechanical ventilation in the treatment of patients with severe respiratory failure and impaired consciousness. Methods Fifty patients with chronic obstructive pulmonary disease (COPD) and severe respiratory failure admitted to Anfu People’s Hospital from January 2010 to January 2014 were divided into observation group (Glasgow Coma Scale (GCS) <10 points] 24 cases and control group (GCS≥10 points) in 26 cases. Two groups of patients underwent noninvasive mechanical ventilation, compared two groups of patients with treatment and before and after arterial blood gas analysis of indicators, including PaO2, PaCO2 and pH values. Results There was no significant difference in the success rate of non-invasive mechanical ventilation between the two groups (79.1% vs 80.7%, P> 0.05). PaO2, PaCO2 and pH values ​​before and after treatment in both groups had no significant difference (P> 0.05). PaO2 was lower in both groups after treatment than before treatment (P <0.05). Conclusion Noninvasive mechanical ventilation has a similar effect on patients with severe respiratory failure or with unconsciousness, which can improve the blood gas analysis indexes.