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卵巢癌是女性生殖系统的第二大恶性肿瘤,在各类女性生殖系统恶性肿瘤中病死率居于首位。黏蛋白(MUC)1是近年来引起广泛关注的用于诊断早期卵巢癌的标志物之一。研究发现,MUC可以充当细胞表面受体和传感器,传递信号刺激细胞反应,如细胞增生、分化和凋亡,异常的MUC表达提示卵巢癌的发生和发展。MUC在卵巢上皮性肿瘤是潜在的肿瘤标志物,在卵巢癌的诊断、治疗及预后判断中可能发挥重要作用。MUC1为一种膜结合型MUC,目前关于MUC1和卵巢癌的研究较多,现就MUC1与卵巢癌关系研究进展进行综述。
Ovarian cancer is the second most malignant tumor of the female reproductive system and ranks first in all kinds of female reproductive system malignancies. Mucin 1 (MUC) 1 is one of the markers for early diagnosis of early ovarian cancer that has drawn much attention in recent years. The study found that MUC can serve as cell surface receptors and sensors, transmit signals to stimulate cellular responses, such as cell proliferation, differentiation and apoptosis, abnormal MUC expression prompted the occurrence and development of ovarian cancer. MUC in ovarian epithelial tumors is a potential tumor marker, which may play an important role in the diagnosis, treatment and prognosis of ovarian cancer. MUC1 is a membrane-bound MUC, the current research on MUC1 and ovarian cancer are more, the research progress of the relationship between MUC1 and ovarian cancer are reviewed.