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【目的】观察健脾化瘀解毒复方胃痞消对胃癌前病变(gastric precancerous lesions,GPL)大鼠胃黏膜组织病理学的影响。【方法】将SD大鼠随机分为正常组,模型组,维酶素组(剂量为0.2 g·kg-1·d-1),胃痞消高、中、低剂量组(剂量分别为15、7.5、3.75 g·kg-1·d-1)。采用N-甲基-N’-硝基-N-亚硝基胍(MNNG)饮用液自由饮用、饥饱失常、耗气泻下法复制GPL大鼠模型,连续18周。从第9周起,给药组按上述剂量连续灌胃给药共10周,观察胃痞消治疗后大鼠胃黏膜上皮的病理学改变。【结果】模型组大鼠胃黏膜肠上皮化生及异型增生的病理积分均较正常组显著升高(P<0.01);胃痞消各剂量组病理学改变均有不同程度改善,并以胃痞消低剂量组作用为佳(P<0.05或P<0.01)。【结论】胃痞消可以从一定程度上阻断和逆转GPL大鼠胃黏膜肠上皮化生及异型增生病变,低剂量胃痞消防治胃癌前病变的远期疗效更佳。
【Objective】 To observe the effect of Jianpi Huayu Jiedu Decoction Weipeixiao on gastric mucosal histopathology in gastric precancerous lesions (GPL) rats. 【Methods】 SD rats were randomly divided into normal group, model group, verapamil group (0.2 g · kg-1 · d-1 dose), Xiaopi high, medium and low dose groups , 7.5, 3.75 g · kg -1 · d -1). The GPL rat model was reproduced by using drinking solution of N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) for drinking freely, starvation, and gas consumption for 18 consecutive weeks. From the 9th week onwards, the rats in the treatment group were given gavage for 10 weeks continuously. The pathological changes of the gastric mucosal epithelium in rats after the treatment of Weipixiao were observed. 【Results】 The histological scores of intestinal metaplasia and dysplasia in model group were significantly higher than those in normal group (P <0.01). The pathological changes in each dose group of Weibixiao group were improved to some extent, Hypogastric low dose group was better (P <0.05 or P <0.01). 【Conclusion】 Weipixiao can block and reverse the gastric mucosal intestinal metaplasia and dysplasia of GPL rats to a certain extent, and the long-term curative effect of low-dose Weipixiao on gastric precancerous lesions is better.