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本试验初步研究了双歧杆菌ＤＭ９２２７菌株及乳杆菌ＤＭ８１２１菌株对大鼠肠菌群失调的调整作用。将含有红霉素及链霉素的抗生素溶液给２０只大鼠灌胃，灌胃量为每种抗生素２０００ｍｇ／ｋｇ／日，连续３天。然后将动物分为双歧杆菌及乳杆菌菌液（ＢＬ）灌胃组及ＰＢＳ灌胃对照组。前者给每只大鼠灌胃含有双歧杆菌ＤＭ９２２７株及乳杆菌ＤＭ８１２１株各为１．５×１０９／ｍｌ的菌液２ｍｌ，每日２次，连续５天；后者以ＰＢＳ灌胃。分别检测抗生素灌胃前、灌胃后，ＢＬ菌液灌胃后及ＰＢＳ灌胃后大鼠的粪菌群成员：肠杆菌、肠球菌、乳杆菌及双歧杆菌。结果表明，抗生素灌胃后诱导产生了大鼠的肠菌群失调，表现出粪便中肠杆菌下降（Ｐ＜０．００１）、肠球菌升高（Ｐ＜０．０５）、乳杆菌及双歧杆菌下降（Ｐ＜０．００１）。ＢＬ菌液能明显纠正肠菌群的失调状态，使上述４种菌恢复到正常水平。
This experiment preliminary study of the bifidobacterium DM9227 strain and Lactobacillus DM8121 strain on the regulation of intestinal flora in rats. The antibiotic solution containing erythromycin and streptomycin to 20 rats gavage, gavage for each antibiotic 2000mg / kg / day for 3 days. Then the animals were divided into Bifidobacterium and Lactobacillus bacteria (BL) gavage group and PBS gavage control group. The former for each rat was intragastrically administered with 2ml of bacterial liquid containing Bifidobacterium DM9227 strain and Lactobacillus DM8121 strain each 1.5x109 / ml twice daily for 5 consecutive days; the latter was intragastrically administered with PBS. The antibiotics were tested before gavage, gavage, BL bacteria gavage and PBS gavage rats after the fecal flora: Enterobacter, Enterococcus, Lactobacillus and Bifidobacterium. The results showed that the intestinal flora of rats was induced by antibiotics after gavage, the enterobacteria decreased (P <0.001), the enterococci increased (P <0.05) Bacilli decreased (P <0.001). BL bacteria can significantly correct the intestinal flora disorders, so that the above four kinds of bacteria returned to normal levels.