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目的 为了探讨子宫内膜异位症发病的免疫机制。方法 采用间接免疫荧光法对子宫内膜异位症患者外周血中的 Ｔ细胞亚群、 Ｂ 细胞， Ｎ Ｋ 细胞及 Ｉ Ｌ－ ２ Ｒ＋ 细胞进行检测，并采用酶联免疫双抗体夹心法对子宫内膜异位症患者外周血及腹腔液中的 Ｔ Ｎ Ｆ－ α浓度进行了检测。结果 子宫内膜异位症患者外周血中 Ｔ 细胞亚群失衡、 Ｂ 细胞增多，外周血及腹腔液中的 Ｔ Ｎ Ｆ－ α浓度显著升高。结论 外周血中 Ｔ 细胞亚群失衡、 Ｂ 细胞增多，腹腔液中 Ｔ Ｎ Ｆα浓度升高可能与子宫内膜异位症的发生，发展密切相关。
Objective To explore the pathogenesis of endometriosis immune mechanism. Methods The T lymphocyte subsets, B cells, N K cells and I L-2 R + cells in peripheral blood of patients with endometriosis were detected by indirect immunofluorescence. The levels of T lymphocyte subsets, T N F-α concentrations in peripheral blood and peritoneal fluid of patients with endometriosis were examined. Results In patients with endometriosis, there was an imbalance of T lymphocyte subsets and increased number of B cells. The concentration of T N F-α in peripheral blood and peritoneal fluid was significantly increased. Conclusions The imbalance of T lymphocyte subsets and the increase of B cells in peripheral blood may be related to the occurrence and development of endometriosis.