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【目的】探讨 QRS波群时限及血浆脑钠肽(BNP)水平预警慢性心衰致心源性猝死(SCD)的可行性。【方法】选择2011年1月至2013年1月期间本院收治的确诊为慢性心衰(CHF)患者210例作为研究对象,持续跟踪测定患者23个月的 QRS波群时限和血浆BNP水平并记录终点事件。比较 SCD患者与心源性非猝死、非心源性死亡、存活心衰患者和健康人群的 QRS波群时限及血浆 BNP 水平差异,分析 SCD发生率与 QRS波群时限及血浆BNP的关系。【结果】198例CHF患者数据完整,按 NYHA评定分级将观察组患者分为三组,QRS波群时限随心功受损加剧而逐级延迟,且差异有统计学意义(P <0.05)；比较三组的血浆BNP水平,心衰 NYHA评级上升则血浆BNP水平增高,组间比较差异有显著性统计学意义(均P <0.01)。SCD组 QRS波群时限高于其他四组,与心源性非猝死组、存活组和健康组差异有统计学意义(P 0.05)；SCD 组 BNP 水平明显高于其他四组,且差异均有显著性统计学意义(P <0.01)【结论】QRS波群时限和血浆BNP水平与CHF患者的 SCD发生率密切相关,联合 QRS波群时限和血浆BNP测定对社区CHF患者进行病情监测具有重要的临床意义。“,”Obj ective]To investigate the feasibility of preventing sudden cardiac death induced by chronic heart failure with QRS duration and serum BNP content.[Methods]From 2011 January to 2013 January,210 CHF patients treated in our hospital were selected.Their QRS duration and serum BNP content were deter-mined for 23 months,and terminal events of patients were recorded.QRS duration and serum BNP content were compared between SCD victims and non-cardiac sudden death group,non-cardiac death group,and survi-vors.The relationship between the incidence of SCD and QRS duration and serum BNP content was then ana-lyzed.[Results]Complete data was obtained from 198 patients.QRS duration of SCD victims was longer than that of the other four groups,and the difference between SCD victims and non-cardiac sudden death group, survivors and healthy controls had statistical significance(P <0.05).Furthermore,serum BNP content of SCD victims was significantly higher than in the other four groups(P <0.01).[Conclusion]QRS duration and serum BNP content are closely correlated with the SCD incidence of CHF patients,and detection of QRS dura-tion and serum BNP content of CHF patients has important significance.