论文部分内容阅读
为探讨２型糖尿病人血清肿瘤坏死因子的变化及其与糖尿病肾病的关系，采用放射免疫分析法测定了３０例２型糖尿病患者和３０例正常人的血清肿瘤坏死因子α水平，结果发现单纯糖尿病组肿瘤坏死因子α水平无明显增高，而糖尿病肾病组肿瘤坏死因子α水平明显升高。患者血清肿瘤坏死因子α水平与空腹血糖、糖化血红蛋白及病程均无相关。提示肿瘤坏死因子α可能在糖尿病肾病发生过程中有重要作用。
In order to investigate the changes of serum tumor necrosis factor (TNF) and its relationship with diabetic nephropathy in type 2 diabetes mellitus, the levels of serum tumor necrosis factor α in 30 type 2 diabetic patients and 30 normal persons were determined by radioimmunoassay. The level of tumor necrosis factor α was not significantly increased, while the level of tumor necrosis factor α in diabetic nephropathy group was significantly increased. Serum tumor necrosis factor-α level and fasting blood glucose, glycosylated hemoglobin and duration were not related. Tumor necrosis factor α may play an important role in the pathogenesis of diabetic nephropathy.