目的评价三维适形放射治疗配合化疗综合治疗局限期小细胞肺癌的意义和疗效。方法将65例局限期小细胞肺癌患者随机分为2组,观察组32例,行EP方案化疗,3周为1周期,共行6个周期,放疗在化疗1个周期后进行,先行常规放射治疗,照射野包括原发病灶和纵隔,照射40Gy后对原发灶行三维适形放射治疗,原发灶总剂量累积达70Gy。放疗期间,化疗照常进行;对照组33例,仅行EP方案化疗,共6周期。结果观察组有效率明显优于对照组(93·75%Vs72·7%,P<0·05),1、2、3年生存率观察组和对照组分别为68%、46%、25%和40%、22%、10%。结论三维适形放射治疗和化疗综合治疗局限期小细胞肺癌是一种安全有效的手段,但长期生存和远期并发症尚需进一步随访。 Objective To evaluate the significance and efficacy of three-dimensional conformal radiotherapy combined with chemotherapy in the treatment of limited-stage small cell lung cancer. Methods Sixty-five patients with localized small cell lung cancer were randomly divided into two groups. The observation group consisted of 32 patients who underwent EP regimen. The patients in the observation group were treated with EP regimen for 3 weeks and 1 cycle for 6 cycles. The radiotherapy was performed after 1 cycle of chemotherapy. Treatment, radiation field, including the primary lesion and mediastinum, 40Gy after irradiation on the primary three-dimensional conformal radiotherapy, the total dose of the primary tumor up to 70Gy. Radiotherapy during chemotherapy as usual; control group of 33 patients, only EP chemotherapy, a total of 6 cycles. Results The effective rate in the observation group was significantly higher than that in the control group (93.75% vs 72.7%, P <0.05). The 1, 2 and 3-year survival rates were 68%, 46% and 25% And 40%, 22%, 10%. Conclusion Three-dimensional conformal radiotherapy and chemotherapy for the treatment of localized small cell lung cancer is a safe and effective means, but long-term survival and long-term complications still need further follow-up.