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IgA肾病是一个以IgA沉积于肾小球系膜区为特点的疾病。至于在免疫荧光所见的免疫沉积物与电镜所见的电子致密物之间的关系及系膜增殖的程度与 IgA沉积物的量之间的关系如何,至今未见到报告。本文对16例IgA肾病进一步作了研究。光镜检查其病变分为三类,即微小病变2例,局灶性系膜增殖性肾炎3例及弥漫性系膜增殖性肾炎11例。同时进行免疫荧光、电镜及免疫电镜检查。结果发现16例电镜见到的电子致密物部位与免疫电镜所见的IgA沉积部位相一致。免疫电镜所见与免疫荧光所见的符合率也在95%以上。微小病变和局灶性系膜增殖性肾炎
IgA nephropathy is a disease characterized by IgA deposition in the mesangial area. No reports have so far been found on the relationship between the immunofluorescent findings of the immunoprecipitates and the electron-dense matter seen on the electron microscope and the relationship between the extent of mesangial proliferation and the amount of IgA deposits. In this paper, 16 cases of IgA nephropathy were further studied. Light microscopic examination of the lesions were divided into three categories, namely, 2 cases of minimal lesions, focal mesangial proliferative glomerulonephritis in 3 cases and diffuse mesangial proliferative glomerulonephritis in 11 cases. At the same time, immunofluorescence, electron microscopy and immunoelectron microscopy. The results showed that the electron-dense sites seen by the 16 electron microscopes were consistent with the IgA deposition sites seen by the immunoelectron microscopy. Immunoelectron microscopy and immunofluorescence seen in line with the rate of 95% or more. Small lesions and focal mesangial proliferative glomerulonephritis