听力对噪声的易感性在噪声所致高血压中的作用

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目的 探讨听力对噪声易感者是否在长期噪声暴露后易患高血压。方法 以 15 93名化肥厂生产工人为研究对象 ,按常规方法收集噪声暴露、听力和血压资料。根据等能量原理将工人的噪声暴露水平和暴露时间合并为累积噪声暴露量 (CNE)。按ISO1999:1990附录A提供的数据对工人的听阈作年龄、性别校正 ,以双耳 3、4、6kHz的校正听阈的平均值为平均高频听阈。以CNE为自变量、平均高频听阈为应变量建立线性回归模型 ,计算高频平均听阈值与线性模型预测值的差值 ,绘制个体易感性分布图。结果 在 15 93名工人中有高血压 193人 ,高血压患病率 12 .1%。高血压患病率随CNE增大而升高 ,差异有显著性 (P <0 .0 1)。个体听力对噪声暴露的易感性为左偏态单峰分布 ,差值范围在- 2 9.8~ 6 4 .8dB之间 ,峰值在 - 5~ 0dB ,中位数为 - 1.8dB。将个体易感性由低至高分组 ,高血压患病率分别为 7.8%、9.0 %、13.3%、18.4 % ,经趋势 χ2 检验 ,差异有显著性 (P <0 .0 1)。多元Logistic回归模型校正了年龄、性别等混杂因素影响后 ,可以观察到CNE的OR值为 1.0 2 5 ,P =0 .0 2 3;在模型中加入个体易感性项目后 ,CNE的OR值为 1.0 31,P =0 .0 0 7,个体易感性高于 5 0 %组的OR值为 1.4 5 4 ,P =0 .0 35。前进法观察OR值发现 ,个体易感性 Objective To investigate whether susceptibility to noise in hearing is susceptible to high blood pressure after prolonged noise exposure. Methods A total of 15 93 workers in fertilizer factories were selected as research objects. Noise exposure, hearing and blood pressure data were collected by routine methods. The worker’s noise exposure level and exposure time are combined into a cumulative noise exposure (CNE) based on the principle of equal energy. According to the data provided in Appendix A of ISO1999: 1990, the average hearing threshold of workers is made as the average high-frequency hearing threshold by the average of the correction hearing thresholds of 3, 4 and 6 kHz of both ears. CNE as an independent variable, the average high frequency threshold as a dependent variable to establish a linear regression model to calculate the difference between the high-frequency average listening threshold and the linear model predictive value, mapping individual susceptibility distribution. As a result, 193 of the 1593 workers had hypertension, and the prevalence of hypertension was 12.1%. The prevalence of hypertension increased with CNE increased, the difference was significant (P <0.01). Individual susceptibility to noise exposure is left-handed unimodal distribution with a range of -2.88-6.48 dB, with a peak at -5 to 0 dB and a median of -1.8 dB. The individual susceptibility from low to high group, the prevalence of hypertension were 7.8%, 9.0%, 13.3%, 18.4%, by the trend χ2 test, the difference was significant (P <0.01). After multivariate Logistic regression model adjusted for age, gender and other confounding factors, the OR of CNE was 1.025, P = .023; after adding individual predisposition to the model, the OR of CNE was 1.031, P = 0.07, OR of individuals with individual susceptibility higher than 50% was 1.4 5 4, P = 0.035. OR method to observe the OR value found that individual susceptibility
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