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目的:探讨运动对糖耐量减低(IGT)患者血管内皮功能的影响。方法:将61名中年IGT患者随机分为健步走组20例、健步走+抗阻力运动组20例和对照组21例,两运动组进行24周运动处方的锻炼。分别于实验前后采用放射免疫法测定受试者内皮素-1(ET-1)和C型利钠肽(CNP);采用彩色多普勒超声诊断仪检测受试者颈动脉内-中膜厚度(IMT)及内皮依赖性血管舒张功能(△Dia-P)。结果:与实验前相比,24周锻炼后,健步走组和健步走+抗阻力运动组CNP水平升高、ET-1水平降低和△Dia-P提高。就实验前后各指标的变化值而言,健步走+抗阻力运动组的CNP、ET-1的变化值显著高于健步走组,差异具有统计学意义。结果表明,健步走或健步走+抗阻力运动可改善中年IGT患者血管内皮功能,健步走+抗阻力运动对CNP、ET-1影响的效果比单纯健步走大。
Objective: To investigate the effect of exercise on vascular endothelial function in patients with impaired glucose tolerance (IGT). Methods: Sixty-one middle-aged patients with IGT were randomly divided into Jianbu walking group (20 cases), walking walking + resistance group (20 cases) and control group (21 cases). Both exercise groups exercised for 24 weeks. The levels of endothelin-1 (ET-1) and C-type natriuretic peptide (CNP) were measured by radioimmunoassay before and after the experiment. The carotid artery intima-media thickness was measured by color Doppler sonography (IMT) and endothelium-dependent vasodilation (△ Dia-P). Results: Compared with those before exercise, CNP level increased, ET-1 level decreased and △ Dia-P increased after 24 weeks of exercise in Jianbu-walk group and Jianbu-walk + anti-resistance exercise group. The changes of CNP and ET-1 in walking and anti-resistance exercise group were significantly higher than those in walking step walking group in terms of the change of each index before and after the experiment, the difference was statistically significant. The results showed that walking or walking exercise + anti-resistance exercise can improve endothelial function in middle-aged IGT patients. The effect of walking and anti-resistance exercise on CNP and ET-1 is greater than that of walking alone.