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目的分析S100B蛋白在不同发作类型、持续时间及不同治疗反应的癫患儿中的表达规律,探索癫患儿脑损伤的评估指标。方法将癫患儿分成未治疗组、控制不良组及控制良好组,测定患儿的血清S100B蛋白浓度。结果癫患儿的血清S100B蛋白浓度显著高于健康对照者(P<0.01),全面性发作组显著高于部分性发作组(P<0.01),发作持续时间>5 min组显著高于发作持续时间<5 min组(P<0.01)。结论血清S100B蛋白有可能作为评估癫患儿脑损伤的指标。
Objective To analyze the expression of S100B protein in children with epilepsy with different types of seizure, duration and response to different treatments, and to explore the assessment of brain damage in children with epilepsy. Methods The children with epilepsy were divided into untreated group, poorly controlled group and well-controlled group. The serum S100B protein concentration in children was measured. Results Serum concentration of S100B protein in children with epilepsy was significantly higher than that in healthy controls (P <0.01), and the incidence of S100B in epileptic children was significantly higher than that in partial seizures (P <0.01) Duration <5 min group (P <0.01). Conclusion Serum S100B protein may be used as an indicator of brain damage in children with epilepsy.