论文部分内容阅读
目的：探讨听觉脑干反应频域参数合成机理。方法：用计算机叠加技术和脑干核团定位技术，分别测试听觉脑干反应（ＡＢＲ） 、耳蜗核腹核听觉诱发反应（ＣＮ－ ＡＥＰ） 、内上橄榄核团内听觉诱发反应（ ＭＳＯ－ ＡＥＰ） 、外侧丘系腹核内听觉诱发反应（ＬＬ－ ＡＥＰ） 和下丘核中央核团内听觉诱发反应（ＩＣ－ ＡＥＰ） 。采用平均功率谱分析方法，对ＡＢＲ及ＡＥＰ的主波单波进行谱分析。结果：豚鼠ＡＢＲ 呈现波Ⅰ、Ⅱ、Ⅲ、Ⅳ四个波，ＣＮ－ ＡＥＰ 中波Ⅱ为主波，ＭＳＯ－ ＡＥＰ波Ⅲ为主波，ＬＬ－ＡＥＰ波Ⅳ为主波，ＩＣ－ ＡＥＰ波Ⅴ为主波，ＡＥＰ中各主波与ＡＢＲ 相对应波潜伏期无显著性差异（Ｐ＞ ０ ．０５） 。与ＡＢＲ 频谱相比，ＡＥＰ各主波单波频谱均存在三个谱能量集中区，即Ｆ０ 、Ｆ１ 和Ｆ２ ，但三谱峰值有不同程度下降，低位脑干以Ｆ２ 下降明显（Ｐ＜ ０ ．０１） ，高位脑干以Ｆ１ 下降明显（Ｐ＜ ０ ．０１） ；各谱峰中心频率向低频移动，频谱带宽变窄。结论：整个听通路各核团均不同程度含有Ｆ１ 和Ｆ２ 固有振荡频率成份。低位脑干以Ｆ２ 合成贡献为主，高位脑干以Ｆ１ 合成贡献为主，Ｆ１ 和Ｆ２ 是多种神经元核团及听神经不同谐振频率所合成。
Objective: To investigate the mechanism of frequency domain parameter synthesis in auditory brainstem response. Methods: The auditory brainstem response (ABR), CN-AEP, MSO-AEP in the olivary nucleus were measured by computer superposition technique and brainstem nucleus localization technique. ), Lateral auditory and supra-nuclear auditory response (LL-AEP) and auditory evoked response (IC-AEP) in the central nucleus of the inferior colliculus. The average power spectrum analysis method was used to analyze the main wave single wave of ABR and AEP. Results: The ABR of guinea pigs showed four waves Ⅰ, Ⅱ, Ⅲ and Ⅳ. The waves of CN-AEP were the main waves, MSO-AEP wave Ⅲ was the main wave, LL-AEP wave Ⅳ was the main wave, As the main wave, there was no significant difference in the corresponding wave latency between ABR and AEP (P> 0.05). Compared with the ABR spectrum, there were three spectral energy concentration regions (F0, F1 and F2) in the single wave spectrum of AEP, but the peaks of three spectrum decreased to different extents. The F2 of low brain stem decreased significantly (P <0. 01). The F1 in high brain stem decreased significantly (P <0.01). The center frequency of each peak shifted to low frequency, and the bandwidth of spectrum narrowed. CONCLUSIONS: The entire auditory access nuclei contain F1 and F2 natural oscillation frequencies to varying degrees. The low brainstem contributes mainly to the synthesis of F2, while the high brainstem contributes mainly to the synthesis of F1. F1 and F2 are synthesized by different kinds of neurons and different resonance frequencies of the auditory nerve.