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目的观察小剂量他巴唑治疗Graves’病临床疗效。方法选择凤城市中心医院2004-01-2005-01门诊114例甲状腺功能亢进症的患者随机分为两组,小剂量组用他巴唑15mg,每天1次口服;普通剂量组用他巴唑30mg,每天1次口服;观察治疗前及用药8周后甲功的变化。FT3 FT4达到正常及治疗到维持阶段所需的时间,粒细胞减少及谷丙转氨酶升高的病例数。结果常规剂量组白细胞减少病例明显多于治疗组(P<0.01)余所有观察指标两组差异均无显著性(P>0.05)。结论小剂量顿服他巴唑治疗甲亢明显优于传统的方法,是一种更安全的治疗方法。
Objective To observe the clinical efficacy of low dose methbazole in treatment of Graves’ disease. Methods A total of 114 patients with hyperthyroidism in Fengcheng Central Hospital from January 2004 to January 2005 were randomly divided into two groups. Small dose group was treated with methimazole 15mg orally once a day. Normal dose group was treated with methimazole 30mg , Once a day orally; observed before treatment and medication after 8 weeks of changes in thyroid function. FT3 FT4 Time to reach normal and treatment-to-maintenance phase, neutropenia and elevated alanine aminotransferase counts. Results Compared with the treatment group (P <0.01), all cases of leukopenia in the conventional dosage group were significantly different (P> 0.05). Conclusion Small doses of daptamonazole treatment of hyperthyroidism was significantly better than the traditional method, is a safer treatment.