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与醇渗漉、醇浸漬等法比较,用醇回流热提法从黄柏提制盐酸小蘖硷有不少优点,因为小蘖硷(Berterine)及其盐类,在热水或在热醇中均极易溶解而易被抽提出来。根据我们经验,通常黄柏生药粉碎成粗细相当于中国药典四号粉后,加95％Alcohol 8——12倍量,在沸水浴上回流热提4——5小时,基本上能将黄柏生药中的苦味成份全部提出。若把上述8——12倍量溶媒分作多次提取,其提出率当能更高,但是在提制过程中消耗酒精量也会多些(註1)。
Compared with the method of alcohol percolation, alcohol impregnation, etc., the use of alcohol reflux heat extraction method to extract hydrochloric acid tincture from phellodendron has many advantages, because Berberine and its salts, in hot water or in hot alcohol Both are easily soluble and easily extracted. According to our experience, usually the Chinese Phellodendron Crushed Crude Drug is crushed to a thickness equal to the Chinese Pharmacopoeia No. 4 powder, and 95% of alcohol is added in 12-fold amount to the product, and it is heated and refluxed on a boiling water bath for 4 to 5 hours. The bitter ingredients are all proposed. If the above 8 - 12 times the amount of solvent is divided into multiple extractions, the proposed rate can be higher, but the consumption of alcohol in the extraction process will be more (Note 1).