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目的:探讨围生期新生儿巨细胞病毒感染的临床特点。方法:对外周血CMV-PP65抗原阳性并伴有临床症状的40例新生儿进行临床分析。结果:①临床表现为肝脏损害:肝脏增大26例,黄疸延迟16例,便白11例,尿黄10例,肝功能改变者40例,体重不增7例;肺损伤:发热15例,咳嗽10例,呼吸促11例,胸片双肺纹理增强11例。②血液系统改变:白细胞数减少7例,贫血27例,血小板减少16例。结论:围生期新生儿巨细胞病毒感染主要表现以肝脏损伤多见,其次为血液系统和肺损伤。
Objective: To investigate the clinical features of neonatal cytomegalovirus infection during perinatal period. Methods: The clinical data of 40 newborns with positive CMV-PP65 antigen in peripheral blood and clinical symptoms were analyzed. Results: ① The clinical manifestations were liver damage: 26 cases of liver enlargement, 16 cases of delayed jaundice, 11 cases of white faeces, 10 cases of urine yellow, 40 cases of altered liver function and 7 cases of body weight loss; lung injury: 15 cases of fever, Cough in 10 cases, breathing in 11 cases, chest X-ray enhancement in 11 cases. ② blood system changes: reduced leukocyte count in 7 cases, anemia in 27 cases, thrombocytopenia in 16 cases. Conclusion: Perinatal neonatal cytomegalovirus infection is mainly manifested as liver damage, followed by blood system and lung injury.