论文部分内容阅读
Objective To investigate the relationship of an insertion/deletion (I/D) polymorphism of the angiotension converting enzyme (ACE) gene to obstructive sleep apnea syndrome (OSAS) patients and the control subjects.Methods Genomic DNA was extracted from blood samples and amplified by polymerase chain reaction (PCR). PCR primers flanked the polymorphic region in intro 16 of the ACE gene. Results OSAS patients had significantly higher frequencies of I/I genotype and insertion allele of the ACE gene as compared with the control subjects in Chinese population. The OSAS patients with I/I genotype had significantly longer apnea time, lower minimum SaO2 and greater AHI than the OSAS patients with I/D genotype. Conclusion These results indicate that the I/I genotype and I allele are a risk factor for OSAS in Chinese.
Objective To investigate the relationship of an insertion / deletion (I / D) polymorphism of the angiotensin converting enzyme (ACE) gene to obstructive sleep apnea syndrome (OSAS) patients and the control subjects. Methods Genomic DNA was extracted from blood samples and amplified by PCR primers flanked the polymorphic region in intro 16 of the ACE gene. Results OSAS patients had significantly higher frequencies of I / I genotype and insertion allele of the ACE gene as compared with the controlling subjects in Chinese population. The OSAS patients with I / I genotype had significantly longer apnea time, lower minimum SaO2 and greater AHI than the OSAS patients with I / D genotype. Conclusion These results indicate that the I / I genotype and I allele are a risk factor for OSAS in Chinese.