胃肠道间质瘤(gastrointestinal stromal tumors,GIST)是胃肠道以及腹腔最常见的间叶源性肿瘤。1983年Magur和Clark提出这一概念之后,经过20年的发展,人们对GIST的起源、基因表达及突变、免疫组化检测、组织学诊断及良恶性的诊断有了较明确的认识。最近Thomas等[1]进行了迄今为 Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the gastrointestinal tract and in the abdominal cavity. After Magur and Clark proposed this concept in 1983, after 20 years of development, people have a clearer understanding of the origin of GIST, gene expression and mutation, immunohistochemical detection, histological diagnosis and benign and malignant diagnosis. Recently Thomas et al. [1] conducted so far