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经60Coγ线照射大鼠肝区,通过光镜(常规HE染色,肝细胞内糖原染色、胶原纤维及网状纤维染色)、电镜和图像分析仪,定量研究了照后1年肘脏的病理改变。结果表明,30Gy组在照射后1年内逐渐发生了放射性肝纤维化病变。在肝纤维化发生过程中,肝细胞内糖原颗粒含量进行性减少,间质中胶原纤维含量进行性增加,网状纤维于照射后1~3个月呈进行性增加。照射后6个月因肝细胞坏死、肝索塌陷,网状纤维呈减少趋势。讨论了上述成分的定量变化在放射性肝纤维化形成中的意义
The 60Coγ ray was used to illuminate the hepatic area of rat and the pathology of the elbow at 1 year after irradiation was studied quantitatively by light microscope (conventional HE staining, intrahepatic glycogen staining, collagen fiber and reticular fiber staining), electron microscope and image analyzer change. The results showed that 30Gy group gradually developed radioactive hepatic fibrosis within 1 year after irradiation. During the process of hepatic fibrosis, the contents of glycogen granules in hepatocytes decreased progressively, the content of collagen fibers in interstitial cells increased progressively, and the reticular fibers increased progressively 1 ~ 3 months after irradiation. 6 months after irradiation due to liver cell necrosis, hepatic collapse, reticular fibers showed a decreasing trend. We discuss the significance of quantitative changes in the above components in the formation of radiation-induced liver fibrosis