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本文探讨30例全血肌酐、尿素氮正常、常规尿蛋白阴性的Ⅱ型糖尿病患者尿白蛋白排泄率与其血压变化的关系。结果表明,收缩压随着尿白蛋白排泄率的增高而渐进性升高。正常组、微量白蛋白尿组以及显性白蛋白尿组之间有显著差异(P<0.01),对舒张压影响不大。因此认为,尿白蛋白排泄率增高是早期糖尿病肾病发生的一个因素,而高血压又可促进或加重糖尿病肾病的发展。早期进行控制血压、减少尿白蛋白排泄的治疗对减少糖尿病肾病发生、发展,降低与高血压相关联的心血管病死亡率的是必要的。
This article discusses the relationship between urinary albumin excretion rate and blood pressure changes in 30 patients with type 2 diabetes who have normal serum creatinine, normal urea nitrogen and normal urine protein. The results showed that systolic blood pressure with urinary albumin excretion rate increased gradually increased. There were significant differences between normal group, microalbuminuria group and dominant albuminuria group (P <0.01), and had little effect on diastolic blood pressure. Therefore, urinary albumin excretion rate is considered to be a factor in the early stage of diabetic nephropathy, and hypertension can promote or aggravate the development of diabetic nephropathy. Early treatment to control blood pressure and reduce urinary albumin excretion is necessary to reduce the incidence and progression of diabetic nephropathy and reduce the cardiovascular mortality associated with hypertension.