Objective: The aim of the present study was to compare the Helicobacter pylori (HP) seropositivity and cytotoxin associated gene A (cagA) status in pregnant women with dyspeptic complaints and pregnant women with no gastrointestinal symptoms. Study design: Seventyone consecutive pregnant women with gastrointestinal complaints and 72 agematched pregnant women without any gastrointestinal symptoms or a history of gastrointestinal disease were included in the study. Demographic characteristics and H. pylori and cytotoxin associated gene A status of the groups were analysed. Results: The prevalence of H. pylori seropositivity was slightly but not significantly higher in patients with dyspeptic complaints compared to the controls (74.6%versus 63.8%, respectively, P>0.05). The incidence of dyspeptic complaints were 53.5%in HPseropositive and 40.9%in HPseronegative women (P>0.05). The prevalence of cytotoxin associated gene A positivity among H. pyloriseropositive women was significantly higher in dyspeptic pregnants compared to the controls (75.5%versus 45.7%, respectively, P=0.002). Among HPseropositive women, the incidence of dyspeptic complaints was significantly higher in cagApositive patients compared to the cagAnegative ones (65.6%versus 34.2%, respectively, P=0.002). When analysed according to the trimesters, the prevalence of cytotoxin associated gene A positivity among H. pyloriseropositive women was significantly higher in dyspeptic pregnants compared to the controls in the first trimester (68.0%versus 34.8%, respectively, P=0.021). Conclusion: Cytotoxin associated gene A-positive, virulant H. pylori strains were found to be more frequently associated with dyspeptic complaints in pregnant women. Objective: The aim of the present study was to compare the Helicobacter pylori (HP) seropositivity and cytotoxin associated gene A (cagA) status in pregnant women with dyspeptic complaints and pregnant women with no gastrointestinal symptoms. Study design: Seventyone consecutive pregnant women with gastrointestinal complaints and 72 agematched pregnant women without any gastrointestinal symptoms or a history of gastrointestinal disease were included in the study. Demographic characteristics and H. pylori and cytotoxin associated gene A status of the groups were analyzed. Results: The prevalence of H . Pylori seropositivity was slightly but not significantly higher in patients with dyspeptic complaints compared to the controls (74.6% vs. 63.8%, respectively, P> 0.05). The incidence of dyspeptic complaints were 53.5% in HP-ger-positive and 40.9% in HPseronegative women (P> 0.05). The prevalence of cytotoxin associated gene A positivity among H. pyloriseropositive women was significantly higher in dyspeptic pregnants compared to the controls (75.5% versus 45.7%, respectively, P = 0.002). Among HPseropositive women, the incidence of dyspeptic complaints was significantly higher in cagApositive patients compared to the cagAnegative ones 65.6% versus 34.2%, respectively, P = 0.002). When analyzed according to the trimesters, the prevalence of cytotoxin associated gene A positivity among H. pyloriseropositive women was significantly higher in dyspeptic pregnants compared to the controls in the first trimester ( 68.0% versus 34.8%, respectively, P = 0.021). Conclusion: Cytotoxin associated gene A-positive, virulant H. pylori strains were found to be more frequently associated with dyspeptic complaints in pregnant women.