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目的了解多西紫杉醇加顺铂及5-氟脲嘧啶(5-Fu)的联合化疗方案治疗进展期胃癌患者的疗效和毒副作用。方法对35例进展期胃癌采用以下化疗方案:多西紫杉醇75 mg/m2,第1天;顺铂25 mg/m2,第1～3天;5-Fu500 mg/m2,第1～5天。每3周为1个周期,至少2个周期。观察化疗后肿瘤原发病灶的缓解情况,并观察化疗的毒副反应。结果临床有效率为51.4%,其中完全缓解(CR)占8.6%(3例),部分缓解(PR)占42.9%(15例),疾病稳定(SD)占34.3%(12例),疾病进展(PD)占14.3%(5例)。毒副反应主要为白细胞减少、恶心、呕吐、腹泻、脱发。共有8例发生了Ⅲ～Ⅳ度的白细胞减少,但未见因此而发生的败血症和死亡病例。结论多西紫杉醇加顺铂及5-Fu的化疗方案治疗进展期胃癌,近期疗效明显,且患者耐受性良好。
Objective To investigate the efficacy and side effects of combination chemotherapy of docetaxel plus cisplatin and 5-fluorouracil (5-Fu) in patients with advanced gastric cancer. Methods The following chemotherapy regimens were used in 35 patients with advanced gastric cancer: docetaxel 75 mg / m2 on day 1; cisplatin 25 mg / m2 on days 1 to 3; and 5-Fu 500 mg / m2 on days 1 to 5. Every 3 weeks for a period of at least 2 cycles. To observe the remission of primary tumor after chemotherapy and to observe the side effects of chemotherapy. Results The clinical effective rate was 51.4%. Complete remission (CR) accounted for 8.6% (3 cases), partial remission (PR) 42.9% (15 cases), stable disease (SD) 34.3% (12 cases) (PD) accounted for 14.3% (5 cases). Toxic side effects mainly leukopenia, nausea, vomiting, diarrhea, hair loss. A total of 8 patients had grade Ⅲ ~ Ⅳ leukopenia, but no sepsis and deaths occurred. Conclusion Docetaxel plus cisplatin and 5-Fu chemotherapy regimen for advanced gastric cancer, the recent curative effect is obvious, and the patient is well tolerated.