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目的 :探讨葛根素、川芎嗪、丹参注射液治疗脑血管疾病的疗效机制。方法 :采用闭合式颅骨开窗法 ,应用多部位微循环观察仪及微循环计算机图像处理系统 ,观察用药前后家兔软脑膜微血管管径及血流速度的变化。结果 :正常家兔静脉注射葛根素 ( 5 0 mg/kg) ,对微血管的管径及血流速度的影响较小 ;静脉注射丹参注射液 ( 1ml/ kg)、川芎嗪 ( 2 0 ml/ kg)、维脑路通 ( 1ml/ kg)均有扩张微动脉、增加微动脉血流速度的作用 ,对微静脉作用较小。其中丹参注射液作用最为明显。结论 :静脉注射丹参注射液、川芎嗪、维脑路通系通过扩张软脑膜微动脉、增加微动脉血流速度而达到治疗目的。
Objective: To explore the therapeutic mechanism of puerarin, tetramethylpyrazine and salvia miltiorrhiza injection in the treatment of cerebrovascular diseases. METHODS: The closed skull window was used, the multi-site microcirculator and microcirculation computer image processing system were used to observe the change of microvessel diameter and blood flow velocity of rabbit pial microvessels before and after treatment. RESULTS: Normal rabbits received intravenous injection of puerarin (50 mg/kg), which had little effect on the diameter and blood flow velocity of the microvessels; intravenous injection of Danshen injection (1 ml/kg) and ligustrazine (20 ml/kg) ), Wei Nao Lu Tong (1ml/kg) have the effect of expanding the arterioles and increasing the blood flow velocity of the arterioles, and have little effect on the venules. Danshen injection plays the most obvious role. Conclusion : Intravenous Salvia miltiorrhiza injection, Tetramethylpyrazine, and Vinorecephalon achieve therapeutic goals by expanding the pial arterioles and increasing the arterial blood flow velocity.