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粘膜是消化道的“皮肤”,复盖干整个胃肠道表面。与呼吸道,泌尿生殖系统的粘液一样,胃粘膜及其分泌的粘液对胃也有重要的保护作用。人们对胃粘膜和粘液可以保护胃组织免于胃蛋白酶和盐酸的侵害早有认识。1954年Hollander提出“双重粘障”(Two-component mucus barrier)学说,根据这个学说,其第一层为复盖于胃内壁的粘液层;第二层为处在粘液下面的高桂状细胞和并排在胃腺小凹周围的矮桂状细胞及立方细胞。近20年来,随着对胃粘液理化性质的了解和药理学的发展,对于粘液的保护作用和药物对粘液的
Mucosa is the “skin” of the digestive tract, covering the entire gastrointestinal tract. And respiratory tract, urogenital mucus, gastric mucosa and its secretion of mucus on the stomach also has an important protective effect. It has long been known that gastric mucosa and mucus can protect stomach tissue against pepsin and hydrochloric acid. Hollander proposed the theory of “Two-component mucus barrier” in 1954, according to which the first layer is the mucus layer that covers the inner wall of the stomach; the second layer is the superficial layer of alginate cells below the mucus, Dwarf Guinea-Pig Cells and Cubic Cells Around Gastric Gland Cavity. Over the past 20 years, with the understanding of the physical and chemical properties of gastric mucus and the development of pharmacology, the protective effect of mucus and drug on mucus