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目的探讨阿托伐他汀对不稳定性心绞痛(UA)患者血浆高敏C-反应蛋白(hs-CRP)的影响。方法测定60例不稳定性心绞痛患者在常规治疗基础上口服阿托伐他汀(商品名立普妥)20mg,治疗12个月前后血浆hs-CRP。结果 60例不稳定性心绞痛患者经阿托伐他汀治疗12个月后血浆hs-CRP显著下降(P<0.01)。结论阿托伐他汀对不稳定性心绞痛患者减少炎症反应起着重要的作用。
Objective To investigate the effect of atorvastatin on plasma high-sensitivity C-reactive protein (hs-CRP) in patients with unstable angina (UA). Methods 60 patients with unstable angina pectoris were treated with oral atorvastatin (Lipitor, 20mg) on the basis of routine treatment, and the plasma hs-CRP was measured before and after treatment for 12 months. Results The plasma hs-CRP levels in 60 patients with unstable angina pectoris after 12 months of atorvastatin treatment were significantly decreased (P <0.01). Conclusions Atorvastatin plays an important role in reducing the inflammatory response in patients with unstable angina.