重组白介素-2(rIL-2)的毒性包括发热、寒颤、流感样综合征、腹泻、恶心、嗜睡和厌食,以及血液、肺、肾、肝和心血管系统作用。血流动力学障碍包括体循环低血压、心动过速、体循环血管阻力(SVR)降低、心指数(CI)增加、左室每搏作功指数降低和左心功能减退。毛细血管通透性增加所致的“毛细血管漏出综合征”可部分解释上述血流动力学改变。若情况严重,这些血流动力学障碍 Toxicity of recombinant interleukin-2 (rIL-2) includes fever, shivering, flu-like syndrome, diarrhea, nausea, lethargy and anorexia, as well as blood, lung, kidney, liver and cardiovascular system effects. Hemodynamic disorders include systemic hypotension, tachycardia, decreased systemic vascular resistance (SVR), increased cardiac index (CI), reduced left ventricular stroke work index and left ventricular dysfunction. "Capillary leak syndrome caused by increased capillary permeability may partially explain the above hemodynamic changes. In severe cases, these hemodynamic disorders