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目的:研究前列宁片抗前列腺增生及抗炎镇痛作用。方法:采用小鼠实验性前列腺增生模型,二甲苯致耳廓肿胀法、角叉菜、5-HT致炎法、热板法、扭体法等多种模型。结果:前列宁片对小鼠实验性前列腺增生有预防和治疗作用;对二甲苯引起的耳廓肿胀及角叉菜、5-HT所致的大鼠足肿胀有抑制作用;可抑制5-HT和组胺所致大鼠毛细血管通透性增加;对小鼠热板法和醋酸扭体法诱发的疼痛有明显的抑制作用。结论:前列宁片具有抗前列腺增生及抗炎镇痛作用
Objective: To study the anti-prostatic hyperplasia and anti-inflammatory and analgesic effects of Qianlining Tablet. METHODS: The mouse model of experimental benign prostatic hyperplasia, xylitol-induced ear swelling, carrageenan, 5-HT inflammation, hot plate method, and writhing method were used. RESULTS: Qianlining tablet could prevent and treat experimental benign prostatic hyperplasia in mice; it had inhibitory effect on xylitol-induced auricular swelling and paw edema caused by chondrone and 5-HT; it could inhibit 5-HT. And histamine-induced rat capillary permeability increased; mouse hot plate method and acetic acid writhing-induced pain has a significant inhibitory effect. Conclusion: Qianlining Tablet has anti-prostatic hyperplasia and anti-inflammatory and analgesic effects