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目的 探讨黑木耳硒多糖对血脂、血硒浓度及谷胱甘肽过氧化物酶活性的影响。方法昆明系雄性小白鼠随机分成四组 :正常对照组 ( )、高脂对照组 ( )、亚硒酸钠组 ( )、硒多糖组( )。 和 组饲喂高脂饲料。并每日每鼠分别灌胃亚硒酸钠或硒多糖水溶液 1 ml(1 .95μg Se/ml) ,共 2 1 d。结果 与 组比 , 、 组小鼠血清 TC显著降低 (P<0 .0 0 1 ) ,GSH- Px活性显著增强 (P<0 .0 0 1 ) ; 组小鼠血清 TG显著降低 (P<0 .0 5) ,血硒浓度显著提高 (P<0 .0 1 ) ; 组小鼠血清 TG显著降低 (P<0 .0 1 ) ,血硒浓度显著提高 (P<0 .0 0 1 ) ;与 组比 , 组硒血浓度显著提高(P<0 .0 0 1 ) ,GSH- Px活性显著增强 (P<0 .0 1 )。结论 硒多糖较亚硒酸钠具有更好的降血脂、提高血硒浓度和增强 GSH- Px活性的作用 ,对高血脂症有一定的预防作用
Objective To investigate the effects of sesame polysaccharide on blood lipids, serum selenium and glutathione peroxidase activity. Methods Male Kunming mice were randomly divided into four groups: normal control group, high fat control group, sodium selenite group and selenium polysaccharide group. Groups were fed high-fat diet. Each rat was intragastrically administered with 1 ml (1.95 μg Se / ml) of sodium selenite or selenium polysaccharide solution for 21 days. Results Compared with the control group, serum TC was significantly decreased (P <0.01) and GSH-Px activity was significantly increased (P <0.01) (P <0.01). Serum TG was significantly decreased (P <0.01) in serum and selenium concentration was significantly increased (P <0.01). Compared with the group, selenium concentration was significantly increased (P <0.01), GSH-Px activity was significantly increased (P <0.01). Conclusion Selenium polysaccharide has better anti-hyperlipidemic effect than sodium selenite, improves blood selenium concentration and enhances the activity of GSH- Px, and has a certain preventive effect on hyperlipidemia