论文部分内容阅读
为了更好地预防卡那霉素中毒性耳聋的发生，通过给豚鼠灌服茯苓煎剂，以一般中毒症状、耳廓反射阈、脑干听觉诱发电位阈及外毛细胞缺失率为指标，观察了茯苓对卡那霉素中毒性耳损害的影响。结果发现服用茯苓煎剂可明显减轻卡那霉素耳损害，服药组和未服药组动物的４ｋＨｚ、６ｋＨｚ、８ｋＨｚ的耳廓反射阈在用药第７天时分别为４．７±１．５ｄＢ、５．７±２．４ｄＢ、２．７±１．２ｄＢ和１０．５±３．２ｄＢ、１２．１±３．７ｄＢ、８．５±２．７ｄＢ。脑干听觉诱发电位阈分别较实验前升高２２．７±９．７ｄＢ和５１．３±１４．４ｄＢ。柯蒂氏器底圈外毛细胞缺失率分别为３９．４％和６７．４％。表明茯苓对卡那霉素中毒性耳损害有对抗作用。
In order to better prevent the occurrence of toxic deafness in kanamycin, guinea pigs were dosed with a decoction to observe general poisoning symptoms, auricular reflex threshold, brainstem auditory evoked potential threshold, and outer hair cell deletion rate as indicators. The effect of earthworms on toxic ear damage in kanamycin. The results showed that the decoction of wolfberry can significantly reduce the kanamycin ear damage. The auricle reflex thresholds of 4 kHz, 6 kHz, and 8 kHz in the drug-administered and non-administered animals were 4.7±1.5 dB on the 7th day of administration. .7±2.4dB, 2.7±1.2dB and 10.5±3.2dB, 12.1±3.7dB, and 8.5±2.7dB. Brainstem auditory evoked potential thresholds were increased by 22.7 ± 9.7 dB and 51.3 ± 14.4 dB, respectively, compared with before the experiment. The loss rate of hair cells outside the bottom of the Kirty instrument was 39.4% and 67.4%, respectively. It was shown that lanthanum has an antagonistic effect on kanamycin in toxic ear damage.