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目的探讨依达拉奉对创伤失血性休克患者氧自由基的清除能力。方法将60例患者按创伤严重程度评分(AIS—ISS 法)。并将16分以上的失血性休克患者随机分为依达拉奉治疗组和对照组两组,每个患者治疗前先抽血测定氧自由基和肝功能。对照组用常规方法治疗,治疗组用依达拉奉治疗,然后再测定氧自由基和肝功能,二者作比较。结果治疗组比对照组的氧自由基明显减少,且肝功能有明显改善,均有统计学意义(P<0.05))。结论依达拉奉有较强的清除创伤失血性休克患者氧自由基的功能,能改善患者肝功能,加速失血性休克患者的恢复。
Objective To investigate the scavenging ability of edaravone on oxygen free radicals in patients with traumatic hemorrhagic shock. Methods Sixty patients were scored according to the severity of trauma (AIS-ISS method). And 16 patients with hemorrhagic shock were randomly divided into edaravone treatment group and control group two groups, each patient before treatment blood oxygen and free radicals and liver function. The control group was treated by conventional method. The treatment group was treated with edaravone, and then the oxygen free radical and liver function were measured. Results Compared with the control group, the oxygen free radicals in the treatment group decreased significantly and the liver function improved significantly (all P <0.05). Conclusion Edaravone has a strong ability to eliminate oxygen free radicals in patients with traumatic hemorrhagic shock, improve liver function and accelerate the recovery of patients with hemorrhagic shock.