论文部分内容阅读
目的探讨老年人脑腔隙梗死(腔梗)与胰岛素抵抗(IR)的关系。方法对354例受试者行空腹血糖(FPG)、甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)检测。采用放免法测定空腹胰岛素(FIN)。评估机体胰岛素抵抗(HOMA-IR),并计算其体重指数(BMI)。将腔梗组按无、有高血压及高 TG/低 HDL 分为Ⅰ、Ⅱ两组。结果腔梗组与健康对照组比较 TG,TC、LDL、FIG、FIN、HOMA-IR 有非常显著差异(P<0.01)。在校正年龄、性别、BMI 后老年人腔梗仍有显著的 IR,且不受高血压和高 TG 的影响。结论老年人腔梗较健康老人有明显的 IR。高 TG、高 LDL、IR 是影响老年人腔梗的可能是独立的危险因素,老年人腔梗与 IR 关系密切,呈正相关。
Objective To investigate the relationship between cerebral infarction (CA) and insulin resistance (IR) in the elderly. Methods Fasting plasma glucose (FPG), triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were measured in 354 subjects. Fasting insulin (FIN) was determined by radioimmunoassay. Body insulin resistance (HOMA-IR) was assessed and its body mass index (BMI) calculated. The lumen group according to no, with high blood pressure and high TG / low HDL divided into Ⅰ, Ⅱ two groups. Results There were significant differences in TG, TC, LDL, FIG, FIN and HOMA-IR between the CAA group and the healthy control group (P <0.01). After adjusting for age, gender, and BMI, there is still significant IR in the elderly, and is not affected by high blood pressure and high TG. Conclusions The lacunar infarction in the elderly has obvious IR compared with healthy elderly. High TG, high LDL, IR are the risk factors that may affect the elderly stems and stools. The elderly patients have a close relationship with IR, and there is a positive correlation between them.