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目的综述细胞膜色谱法(cell mumbrane chromatography,CMC)近几年的研究现状及发展。方法查阅国内外有关文献,从CMC的基本原理、特点及其在药物研究中的应用等最新研究进展进行较为详细的介绍和总结,并探讨其在发展中所面临的问题及对策。结果CMC已成功应用于中药药效物质基础研究、中药质量控制、单体化合物活性筛选、药物与受体及受体亚型亲和作用研究等方面,并且CMC在不断的发展和完善。结论随着CMC研究的不断深入,其在药物研究、分析领域等方面具有广阔的发展前景。
Objective To summarize the research status and development of cell mumbrane chromatography (CMC) in recent years. Methods To review the literature at home and abroad, and to introduce and summarize the latest research progress, such as the basic principles and characteristics of CMC and its application in drug research, and to discuss its problems and countermeasures in the development. Results CMC has been successfully applied to the research of traditional Chinese medicine (TCM), quality control of traditional Chinese medicine (TCM), activity screening of monomer compounds, affinity between drug and receptor and its receptor subtypes. CMC has been continuously developed and improved. Conclusion With the deepening of CMC research, it has broad prospects for development in the field of drug research and analysis.