论文部分内容阅读
目的比较观察丙戊酸钠和苯妥英钠两种药物治疗癫痫的疗效和安全性。方法将183例癫痫患者随机分为丙戊酸钠组96例和苯妥英钠组87例。丙戊酸钠组给予丙戊酸钠治疗,苯妥英钠组给予苯妥英钠治疗。随访3年观察两组临床疗效和不良反应情况。结果治疗后,两组总有效率差异无统计学意义(P>0.05);丙戊酸钠组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论丙戊酸钠和苯妥英钠治疗癫痫均有较好的疗效,可改善患者临症状,降低发作频率,但丙戊酸钠不良反应发生率低于苯妥英钠,安全性更佳,因此临床治疗癫痫应优先选择丙戊酸钠。
Objective To compare the efficacy and safety of two drugs, sodium valproate and phenytoin, in the treatment of epilepsy. Methods 183 patients with epilepsy were randomly divided into sodium valproate group 96 cases and phenytoin sodium group 87 cases. Patients in the valproate group were given sodium valproate, and those in the phenytoin group were treated with phenytoin sodium. Followed up for 3 years to observe the clinical efficacy and adverse reactions in both groups. Results After treatment, there was no significant difference in the total effective rate between the two groups (P> 0.05). The incidence of adverse reactions in the sodium valproate group was lower than that in the control group (P <0.05). Conclusions Both sodium valproate and phenytoin sodium have better curative effect on epilepsy, which can improve the clinical symptom and reduce the frequency of seizure. However, the incidence of adverse reactions of sodium valproate is lower than that of phenytoin sodium, so it is more safe and therefore clinical treatment of epilepsy Should be preferred sodium valproate.