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目的：研究声门上型喉癌组织中ｎｍ２３／ＮＤＰＫ的表达及与癌恶性度和颈淋巴结转移之间的关系。方法：应用免疫组化Ｓ－Ｐ法。结果：８０例喉癌原发灶中ＮＤＰＫ表达阳性率５８．８％；其中无颈淋巴结转移者阳性率为６９．８％，伴有颈淋巴结转移者阳性率４５．８％，差异有显著性意义（Ｐ＜０．０５）。低度恶性原发灶中ＮＤＰＫ表达阳性率６８．８％，高度恶性阳性率４５．９％，差异有显著性意义（Ｐ＜０．０５）。高度恶性原发灶ＮＤＰＫ表达阴性病例颈淋巴结转移率显著高于低度恶性ＮＤＰＫ表达阳性病例颈淋巴结转移率（Ｐ＜０．０１）。结论：ｎｍ２３基因在声门上型喉癌颈淋巴结转移过程中发挥负性调控作用。
Objective: To investigate the expression of nm23 / NDPK in supraglottic laryngeal carcinoma and its correlation with the degree of malignancy and cervical lymph node metastasis. Methods: The immunohistochemical S-P method was used. Results: The positive rate of NDPK expression in primary laryngeal carcinoma was 58.8% in 80 cases. The positive rate of NDPK in non-cervical lymph node metastasis was 69.8%, while the positive rate of cervical lymph node metastasis was 45.8%, the difference was significant Significance (P <0.05). The positive rate of NDPK in low grade malignant tumor was 68.8%, the positive rate was 45.9%, the difference was significant (P <0.05). The rate of cervical lymph node metastasis in patients with highly malignant neoplasm with NDPK negative expression was significantly higher than that in patients with low grade NDPK positive expression (P <0.01). Conclusion: nm23 gene plays a negative regulatory role in cervical lymph node metastasis of supraglottic laryngeal carcinoma.