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婴儿肠道细菌感染不仅可引起小肠结肠炎,也可侵犯中枢神经系统和(或)引起全身性感染.荚膜抗原(K)是致病细菌的毒性所在.近年来分离出含K_1抗原的菌株.K_1抗原属多糖类.含K_1抗原的大肠杆菌对婴儿,尤其是新生儿有其特殊毒性作用.并证明疾病的严重性和予后与K_1抗原的含量有关.大肠杆菌的K_1抗原和脑膜双球菌的荚膜抗原有共同性.故认为这种大肠杆菌嗜神经性,选择性作用于中枢神经系统而引起脑膜炎,但在腹泻的发病上作用不大.含K_1抗原的菌株也有抗细胞吞噬和抗补体的作用,可引起败血症.
Infectious enterocolitis in infants not only causes enterocolitis, but also invades the central nervous system and / or causes systemic infections. The capsular antigen (K) is the virulence of pathogenic bacteria. In recent years, strains containing the K 1 antigen have been isolated .K_1 antigen is a polysaccharide.K1 antigen-containing Escherichia coli in infants, especially newborns have special toxic effects and to prove the severity of the disease and post-adjuvant K_1 antigen content of K_1 E. coli and the brain membrane Diphtheria capsular antigen common, so that this kind of Escherichia coli neurotropic, selectively acting on the central nervous system and cause meningitis, but little effect on the incidence of diarrhea K1 antigen-containing strains also have anti-cell Phagocytosis and anti-complement effect, can cause sepsis.