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本文主要介绍对立违抗障碍(oppositional defiant disorder,ODD)、5-羟色胺(5-hydroxy tryptamin,5-HT)的相关概念以及论述它们之间的关系。ODD的发病机理目前尚未明确,涉及生物学、社会心理学等。5-HT系统异常在ODD发病过程中有着重要的作用。文章就5-HT的角度来阐述其与ODD的关系,主要从5-HT相关基因、5-HT受体、5-HT信号传导等予以综述。
This article describes the concepts of oppositional defiant disorder (ODD) and 5-hydroxytryptamin (5-HT) as well as the relationship between them. The pathogenesis of ODD is not yet clear, involving biology, social psychology and so on. 5-HT system abnormalities play an important role in the pathogenesis of ODD. This article describes the relationship between ODD and 5-HT, mainly from 5-HT related genes, 5-HT receptors, 5-HT signaling and so on.