目的　了解强直性脊柱炎 (AS)骶髂关节 (SIJ)内皮质激素注射的疗效。方法　患者取俯卧位 ,在CT导引下穿刺SIJ滑膜部 ,取组织标本后 ,在CT导引下原路进入SIJ ,每侧注入丙酮缩去炎舒松 15mg。记录分析病人术前、术后临床资料。结果　 2 8例中 2 2例 (78 6 % )疼痛明显减轻 ,晨僵、夜间痛、SIJ压痛、“4”征、ESR升高及需使用NSAIDs的例数均较术前明显减少。所有SIJ标本均有炎症表现。结论　SIJ关节内注射长效激素 ,可作为对NSAIDs不耐受或无效的AS和uSpA病人的一种有效的缓解腰背痛手段 ,同时uSpA病人SIJ病理标本的获得 ,有助于早期诊断 Objective To investigate the effect of injecting corticosteroid into sacroiliac joint (SIJ) in ankylosing spondylitis (AS). Methods The patient was placed in the prone position and the SIJ synovial membrane was punctured under CT guidance. After taking the tissue samples, the patients were infiltrated into the SIJ under the guidance of CT and infused with 15 mg of acetone. Record and analyze the patient’s preoperative and postoperative clinical data. Results Twenty-eight of 28 cases (78.6%) had obvious pain relief. Morning stiffness, nocturnal pain, tenderness of SIJ, signs of “4”, increased ESR and the number of NSAIDs needed were significantly lower than those before operation. All SIJ specimens showed inflammation. CONCLUSION SIJ intra-articular injection of long-acting hormones may be an effective means of relieving low back pain in AS and uSpA patients who are intolerant or ineffective with NSAIDs. The acquisition of SIJ pathological specimens in uSpA patients may be helpful for early diagnosis