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Phytochemical investigation of the aerial parts of Leonurus japonicus led to the isolation of one unusual clerodane diterpenoid,leojaponin A(1),characterized by a C4–C7oxa-bridge,and two new labdane diterpenoids,leojaponins B(2) and C(3).The structures of these new compounds were determined based on extensive 1D and 2D NMR spectroscopic data.To the best of our knowledge,compound 1 is the first clerodane diterpenoid obtained from Leonurus.japonicus.All of them were evaluated for their cytotoxicity.
Phytochemical investigation of the aerial parts of Leonurus japonicus led to the isolation of one unusual clerodane diterpenoid, leojaponin A (1), characterized by a C4-C7oxa-bridge, and two new labdane diterpenoids, leojaponins B (2) and C The structures of these new compounds are determined based on extensive 1D and 2D NMR spectroscopic data. To the best of our knowledge, compound 1 is the first Clerodane diterpenoid obtained from Leonurus. Japonicus. All of them were evaluated for their cytotoxicity.