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目的:探讨长期低水平铅接触对人体免疫功能的影响。方法:选择某蓄电池厂男性作业工人295人为铅接触组(从中选取叠片、灌粉、铸造、打磨、烧焊等生产岗位工人86人作为高铅组,选取巡检、维修、化成等辅助岗位工人74人作为低铅组),随机选取同地域男性非铅接触工作人员339人作为对照组,测定其血铅和血清免疫球蛋白(IgA、IgG、IgM)、补体(C3、C4)、白介素2(IL-2)、肿瘤坏死因子α(TNF-α)含量。结果:铅接触组血铅浓度高于对照组,差异有统计学意义(P<0.05);IgG、IgM、C3、C4低于对照组,差异有统计学意义(P<0.05)。高铅组和低铅组血铅浓度差异有统计学意义(P<0.05),但IL-2、TNF-α差异无统计学意义(P>0.05)。结论:长期低水平铅接触对人体免疫功能有一定的抑制作用。
Objective: To investigate the effect of long-term low level lead exposure on human immune function. Methods: A total of 295 male workers in a battery factory were chosen as the lead exposure group (86 workers in production positions were chosen as the high-lead group, such as lamination, powder filling, casting, grinding, welding and so on. 74 workers were taken as the low lead group). 339 non-lead contact workers in the same region were randomly selected as the control group. Blood lead and serum immunoglobulin (IgA, IgG, IgM), complement (C3, C4), interleukin 2 (IL-2), tumor necrosis factor alpha (TNF-alpha) content. Results: The level of blood lead in lead exposure group was higher than that in control group (P <0.05). The levels of IgG, IgM, C3 and C4 in control group were lower than those in control group (P <0.05). There were significant differences in blood lead levels between high lead group and low lead group (P <0.05), but there was no significant difference between IL-2 and TNF-α (P> 0.05). Conclusion: Long-term low level lead exposure may have certain inhibitory effect on human immune function.