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探讨肾素—血管紧张素Ⅱ—醛固酮系统（ＲＡＳ）在肾脏疾病中变化的意义，研究了２６例慢性肾功能衰竭病人的肾素、血管紧张素Ⅱ、醛固酮（ＰＲＡ、ＡⅡ、Ａｌｄ）及血Ｋ＋、Ｎａ＋、Ｃｌ－、ＨＣＯ３－、ｐＨ的变化。结果表明：肾功能恶化程度与肾素、血管紧张素Ⅱ的增高程度差别有显著性，Ｐ＜０．０５，而与醛固酮水平差别无显著性，Ｐ＞０．０５。结论：测定血清ＰＲＡ、ＡⅡ、Ａｌｄ浓度可指导临床用药、估计预后、判断治疗效果，并为ＡＣＥ┐Ⅰ治疗慢性肾功能衰竭提供了理论依据。
To investigate the significance of renin-angiotensin Ⅱ-aldosterone system (RAS) in renal diseases and the relationship between renin, angiotensin Ⅱ, aldosterone (PRA, AⅡ, Ald) and blood in 26 chronic renal failure patients K +, Na +, Cl-, HCO3-, pH changes. The results showed that there was a significant difference between the degree of renal dysfunction and the increase of renin and angiotensin Ⅱ, P <0.05, but no significant difference with aldosterone level (P> 0.05). Conclusion: Determination of serum PRA, A Ⅱ, Ald concentration can guide the clinical medication, prognosis, to determine the therapeutic effect, and provide a theoretical basis for ACE â ... ¢ treatment of chronic renal failure.