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异三尖杉酯碱(Isoharringtonine)为三尖杉属植物(Cephalotaxus)所含具有抗癌活性的四种酯碱之一。我们曾报道过一条合成异三尖杉酯碱(3)的成功路线[见本刊,27(1982),1048],本文再介绍一种应用交叉Pinacol反应一步合成异三尖杉酯碱(3)的新方法,其反应式如下:
Isoharringtonine is one of the four esterases with anticancer activity contained in Cephalotaxus. We have previously reported a successful route to the synthesis of homoharringtonine (3) [27 (1982), 1048]. This article describes a one-step synthesis of homoharringtonine (3 ) The new method, the reaction is as follows: