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目的:通过第二代杂交捕获(hc-2)人乳头瘤病毒(HPV)DNA检测,探讨hc-2在宫颈病变筛查中临床运用价值。方法:2006年6月～2008年3月,江苏省常州市妇幼保健院对2 834例宫颈疾病妇女进行HPV、阴道镜检查及病理组织学检查。结果:高危型HPV检测阳性998例,阳性率35.2%(998/2 834)。结合宫颈细胞学检查,对部分病人行阴道镜检查及病理组织学诊断,在199例宫颈上皮内瘤变病人中,174例HPV检测为阳性,阳性率87.4%(174/199)。其中CINⅠ32例,CINⅡ48例,CINⅢ62例(CINⅢ57例、原位癌5例),宫颈鳞癌56例,宫颈腺癌1例(宫颈癌共57例)。HPV阳性率分别为75.0%、81.3%、91.9%、94.7%。随病变加重,高危型HPV感染率逐渐增高。结论:HPV检测在基层初筛高危人群有积极的作用。
Objective: To investigate the clinical value of hc-2 in the screening of cervical lesions by second-generation hybridization (hc-2) human papillomavirus (HPV) DNA test. METHODS: From June 2006 to March 2008, 2,834 women with cervical diseases underwent HPV, colposcopy and histopathological examinations in Changzhou Maternal and Child Health Hospital of Jiangsu Province. Results: 998 cases of high-risk HPV test positive, the positive rate of 35.2% (998/2 834). Combined with cervical cytology, some patients underwent colposcopy and histopathological diagnosis, of 199 cases of cervical intraepithelial neoplasia patients, 174 cases of HPV was positive, the positive rate of 87.4% (174/199). Among them, 32 cases of CINⅠ, CINⅡ48 cases, CINⅢ62 cases (CINⅢ57 cases, carcinoma in situ in 5 cases), cervical squamous cell carcinoma 56 cases, cervical adenocarcinoma 1 case (cervical cancer 57 cases). The positive rates of HPV were 75.0%, 81.3%, 91.9% and 94.7% respectively. As the disease aggravates, the high-risk HPV infection rate gradually increases. Conclusion: The HPV test plays a positive role in the screening of high-risk groups at the grass-roots level.