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目的 :观察胃祺 号方对大鼠胃窦、胃底部一氧化氮 (NO)含量的影响 ,探讨其可能的作用机制。方法 :采用大鼠胃电节律失常模型 ,以硝酸还原酶法测定胃窦和胃底部 NO的含量。结果 :与正常组比较 ,模型组大鼠胃窦 NO含量显著升高 (P <0 .0 1) ,而胃底部 NO含量显著降低 (P <0 .0 5 )。胃祺 号方组胃窦部 NO的含量较模型组显著降低 (P <0 .0 1) ,而胃底部 NO的含量较模型组显著升高 (P <0 .0 5 ) ,与正常组相仿。结论 :胃祺 号方能升高胃底部 NO的含量 ,降低胃窦部 NO的含量 ,可能是其治疗功能性消化不良的重要机制。
Objective : To observe the effect of Weishuhaohaofang on the content of nitric oxide (NO) in the gastric antrum and gastric fundus of rats and to explore its possible mechanism. Methods : Rat stomach electrical arrhythmia model was used to determine the content of NO in gastric antrum and stomach bottom by nitrate reductase method. RESULTS: Compared with the normal group, NO content in the gastric antrum of the model group increased significantly (P < 0.01), while NO content in the gastric fundus decreased significantly (P <0.05). Compared with the model group, the content of NO in gastric antrum was significantly decreased in the Stomach-Qinghao group (P < 0.01), while the content of NO in the gastric fundus was significantly higher than that in the model group (P <0.05). similar. Conclusion : The Stomach-Qi can increase the content of NO at the bottom of stomach and decrease the content of NO in gastric antrum, which may be an important mechanism for the treatment of functional dyspepsia.