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目的 探讨慢性乙型肝炎患者血清白细胞介素 6 (Interleukin 6 ,IL 6 )与乙型肝炎病毒(HBV)复制的关系及其在肝脏病理损伤中的作用。方法 对 6 6例不同类型的乙型肝炎标志物阳性患者及不同程度的慢性乙型肝炎患者血清IL 6水平进行检测 ,同时检测HBV复制标志物———多聚人血清白蛋白受体 (polymerizedhumanserumalbuminreceptor,PHSA R)。结果 HBV携带组及轻度慢性乙型肝炎组中PHSA R阳性患者血清IL 6水平高于PHSA R阴性患者 (P <0 .0 1) ;38份PHSA R阳性患者PHSA R检测吸光度A值与血清IL 6水平显著相关 ,r =0 .6 94(P <0 .0 1) ;血清IL 6水平按乙型肝炎病情严重程度依次增高。结论 血清IL 6水平与HBV复制及肝脏损伤程度相关 ,血清IL 6水平检测作为指示乙型肝炎患者HBV的复制及辅助病情和疗效的判定 ,可能是一个新的有价值的指标
Objective To investigate the relationship between Interleukin 6 (IL 6) and hepatitis B virus (HBV) replication in patients with chronic hepatitis B and its role in the pathological liver injury. Methods Sixty-six patients with different types of hepatitis B and those with different degrees of chronic hepatitis B were assayed for serum IL-6 levels. At the same time, the levels of HBV replication marker, polymerized human serum albumin receptor , PHSA R). Results The levels of serum IL-6 in PHSA R positive patients in HBV-carrying group and mild chronic hepatitis B group were higher than those in PHSA R negative patients (P <0.01); 38 PHSA R positive patients PHSA R absorbance A value and serum IL 6 levels were significantly correlated, r = 0. 6 94 (P <0.01); serum IL 6 levels in accordance with the severity of hepatitis B were increased. Conclusions Serum IL-6 level is correlated with the degree of HBV replication and hepatic injury. Detection of serum IL-6 levels may be a valuable new indicator as a measure of HBV replication, complementary disease and efficacy in patients with hepatitis B