论文部分内容阅读
水泡液中药物浓度的高低对感染的治疗是重要的,因为多数细菌感染是发生在组织间隙.许多研究者一直在探讨β-内酰胺抗生素渗透入组织间液的浓度及其与蛋白结合率之间的关系.本文评价了头孢尼西、头孢唑肟和头孢噻肟三种药的蛋白结合率对药物渗透进入水泡液的影响.头孢尼西的蛋白结合率高约98%,而头孢唑肟和头孢噻肟为40%.实验采用改良的吸引水泡形成技术,比较了三种药物在水泡液中药物浓度的差异.实验结果在水泡表面积与水泡液量比率大的水泡中,药物浓度比水泡表面积与水泡液比率小的水泡中的药物浓度更接近于血清
The level of drug in the blister fluid is important for the treatment of infection because most bacterial infections occur in the interstitial spaces Many investigators have been investigating the concentration of β-lactam antibiotics that penetrate interstitial fluid and their association with protein binding This article evaluated the effect of the protein binding rate of cefonicid, ceftizoxime and cefotaxime on the drug infiltration into the blister fluid with a high protein binding rate of about 98% for cefonicid, while the effect of ceftizoxime And cefotaxime was 40% .According to the improved suction blister formation technique, the difference of drug concentration in three blister fluid was compared.Experimental results showed that in the blisters with large ratio of blister surface area to blister volume, the drug concentration was higher than blister The concentration of drug in the blisters with a small surface area to blister ratio is closer to the serum