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目的 :研究那屈肝素钙对急性脑梗死病人血液流变学和脑血流量的影响。方法 :80例分为治疗组和对照组各 4 0例 ,2组均予以复方丹参 2 0mL ,加入氯化钠注射液 2 5 0mL ,iv ,gtt ,qd ,疗程 10d。治疗组加用那屈肝素钙 4 10 0IU ,ip ,q 12h ,共10d。治疗前后检查病人血液流变学指标和脑血流量。结果 :那屈肝素钙治疗组总有效率 82 % ,对照组 5 8% ,2组疗效比较 ,P <0 .0 5。 2组治疗后血液流变学指标和脑血流量均有所改善 (治疗组和对照组血浆比粘度差值分别为 - 1.2 3± 0 .2 1和 - 0 .19± 0 .0 4 ,血小板粘附率为 (- 13.0± 1.8) %和 (- 6 .2± 1.7) % ,以治疗组尤为明显 (P <0 .0 5或 <0 .0 1)。结论 :那屈肝素钙能有效治疗急性脑梗死 ,改善病人血液流变学和脑血流量
Objective: To study the effects of nadroparin calcium on hemorheology and cerebral blood flow in patients with acute cerebral infarction. Methods: 80 cases were divided into treatment group and control group, 40 cases in each group. Two groups were given 20ml Salvia miltiorrhiza. 250ml sodium chloride injection was added, iv, gtt, qd for 10 days. Treatment group plus nadroparin calcium 4 10 0IU, ip, q 12h, a total of 10d. Before and after treatment to check the patient’s blood rheology indicators and cerebral blood flow. Results: The total effective rate of nadroparin calcium group was 82% and that of the control group was 58%. The curative effect of the two groups was P <0. 05. After treatment, the indexes of hemorheology and cerebral blood flow were improved in both groups (the difference in plasma specific viscosity between the treatment group and the control group was - 1.2 3 ± 0.21 and -0.19 ± 0.4, respectively. Platelets The adhesion rate was (-13.0 ± 1.8)% and (-6.2 ± 1.7)%, respectively, especially in the treatment group (P <0.05 or <0.01) .Conclusion: Nadroparin calcium can be effective Treatment of acute cerebral infarction, improve patient hemorheology and cerebral blood flow