论文部分内容阅读
目的:探讨母体血清妊娠相关血浆蛋白A(PAPP-A)、人绒毛膜促性腺激素游离β亚单位(Fβ-hCG)联合胎儿颈部透明带(NT)超声在孕早期胎儿染色体非整倍体异常筛查中的意义。方法:研究开展时间开始于2013年1月至2016年12月,共2800例孕妇,根据检测结果划分为阴性组、阳性组、唐氏综合征组。若血清PAPP-A、Fβ-hCG水平、NT值检测结果为异常结果,则进行进一步产前染色体检查,确诊是否属于唐氏综合征患儿。检测患者血清PAPP-A、Fβ-hCG水平。使用彩超设备检测胎儿的NT值。对比三组孕妇的血清PAPP-A、Fβ-hCG、NT水平。结果:和唐氏综合征组对比,阴性组血清PAPP-A水平明显更高,Fβ-hCG水平、NT水平明显更低,差异具有统计学意义(P<0.05);阳性组血清PAPP-A水平明显更高,Fβ-hCG水平、NT水平明显更低,差异具有统计学意义(P<0.05)。结论:孕早期使用超声检测胎儿NT厚度,结合母体血清PPAP-A、Fβ-hCG检测,可有效地诊断胎儿唐氏综合征,有利于减少该疾病给患者所造成的身心伤害。
Objective: To investigate the relationship between maternal serum pregnancy-associated plasma protein A (PAPP-A), human chorionic gonadotrophin free beta subunit (Fβ-hCG) and fetal cervical zona pellucida (NT) The significance of abnormal screening. Methods: The study began in January 2013 to December 2016, a total of 2,800 pregnant women, according to the test results were divided into negative group, positive group, Down Syndrome group. If the serum PAPP-A, Fβ-hCG levels, NT value of the test results for the abnormal results, then further prenatal chromosome examination to determine whether the children belong to Down Syndrome. Serum PAPP-A, Fβ-hCG levels were measured. The use of ultrasound equipment to detect fetal NT value. The levels of serum PAPP-A, Fβ-hCG, NT in three groups of pregnant women were compared. Results: Compared with Down Syndrome group, the serum PAPP-A level in the negative group was significantly higher, the levels of Fβ-hCG and NT were significantly lower, the difference was statistically significant (P <0.05); the serum PAPP-A level Significantly higher, Fβ-hCG levels, NT levels were significantly lower, the difference was statistically significant (P <0.05). CONCLUSIONS: Using fetal ultrasound to detect fetal NT thickness in early pregnancy can effectively diagnose fetal Down Syndrome in combination with maternal serum PPAP-A and Fβ-hCG, which is beneficial to reduce the physical and psychological damage caused to the patient.