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足细胞,作为肾小球滤过屏障的一道重要防线,被认为是蛋白尿产生的中心环节,因此近年来备受关注。免疫抑制剂对足细胞损伤的保护作用促使人们寻找除其免疫抑制作用之外对足细胞直接的保护机制,足细胞本身是否具有免疫细胞样的特性?在病理情况下,足细胞又是如何对机体炎症反应作出应答的?上述川题的解答将对足细胞损伤机制研究和探寻治疗干预措施具有重要意义。
Podocyte, an important line of defense of the glomerular filtration barrier, is considered as the central part of the proteinuria. Therefore, it has drawn much attention in recent years. The protective effect of immunosuppressants on podocyte injury urges people to look for a direct protective mechanism for podocytes in addition to their immunosuppressive effects. Does the podocyte itself have an immunocyto-like property? How are podocytes under pathological conditions? Body inflammatory response to respond? The above questions Sichuan answer the question of podocyte injury mechanism research and explore therapeutic interventions of great significance.