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为了了解铝的胚胎毒性，用实验畸胎学的方法，研究了孕期里经口摄入不同剂量铝对妊娠小鼠宫内胚胎发育的影响。结果发现，铝的过量摄入对小鼠胚胎发育具有明显的致畸作用和毒性。它可导致胚胎发生露脑畸形和骨发育不全，及胎儿宫内生长迟缓和小鼠胚胎死亡率升高，并表现出明显的剂量－效应关系。提示，铝的过量摄入可能是先天性神经管缺陷（ＮＴＤｓ）和胎儿宫内生长迟缓（ＩＵＧＲ）以及围产儿死亡的危险因素之一。
In order to understand the embryotoxicity of aluminum, we used the method of experimental teratology to study the effect of oral intake of different doses of aluminum during pregnancy on intrauterine embryonic development in pregnant mice. The results showed that excessive aluminum intake on mouse embryonic development has significant teratogenicity and toxicity. It can result in embryonic brain deformities and hypoplasia, as well as delayed intrauterine growth and increased mouse embryo mortality, with a clear dose-response relationship. It is suggested that excess aluminum intake may be one of the risk factors of congenital neural tube defects (NTDs) and fetal growth retardation (IUGR) and perinatal death.