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目的探讨血小板相关参数与单采血小板输注疗效之间的相关性,为临床诊断提供指导意义。方法通过回顾性的分析本院2014-2016年输注单采血小板的患者50例,根据首次输注1个治疗量血小板后d 5复查血常规结果,血小板计数升至正常范围为增长组(27人),血小板计数未达正常范围为降低组(23人)。分别比较分析2组输注前和输注后24 h内血小板相关系数包括血小板计数(Plt),血小板分布宽度(PDW),平均血小板体积(MPV),大血小板比率(P-LCR)的改变,同时计算24 h血小板纠正计数指数(CCI)。结果 24 h CCI>4.5增长组有21例占77.78%,降低组有11例占47.83%;输注前血小板相关参数两组间比较没有显著差异(P>0.05),输注后,增长组Plt,PDW,MPV和P-LCR明显高于降低组(P<0.01);其中输血前后数据相比较增长组MPV,P-LCR全部增高,降低组MPV,P-LCR则全部降低。结论血小板参数检测特别是MPV和P-LCR的改变趋势对于血小板输注的疗效观察与预后判断具有重要的临床意义。
Objective To investigate the correlation between platelet-related parameters and the effect of apheresis platelet transfusion, and provide guidance for clinical diagnosis. Methods By retrospectively analyzing 50 patients with single platelet transfusion in our hospital from 2014 to 2016, according to the results of routine blood routine examination at day 5 following the first infusion of a therapeutic platelet, the platelet count rose to the normal range for the growth group (27 Person), platelet count did not reach the normal range for the reduction group (23). The correlation coefficients of platelet including platelet count (Plt), platelet distribution width (PDW), mean platelet volume (MPV), and large platelet ratio (P-LCR) were compared between the two groups before and 24 h after infusion. The 24 h platelet count index (CCI) was also calculated. Results In 24 h CCI> 4.5, 21 cases accounted for 77.78% in the growth group and 11 cases in the reduction group accounted for 47.83%. There was no significant difference between the two groups (P> 0.05) (P <0.01). The levels of MPV and P-LCR in all the groups before and after transfusion were higher than those in the control group (P <0.01). The levels of MPV and P-LCR in the decreasing group were all decreased. Conclusion The change of platelet parameters, especially the changes of MPV and P-LCR, have important clinical significance for the observation and prognosis of platelet transfusion.